Allyl chloroformate → HCID 59244570, compound

Participants

Reaction Steps

Using bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (41.4 mg, 0.0769 mmol) and allyl chloroformate (17 μl, 0.160 mmol) instead of acetic anhydride, in the same manner as Example 1-D-01, a crude product of 4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid allyl ester was obtained, and deprotection was further carried out according to the above deprotection reaction method 1, to obtain the desired compound (D-40) as a colorless powder (27.0 mg, 92%).

Provenance & Evidence