N,N-Dimethylethylenediamine → 4-[4-(2-Amino-pyrimidin-5-yl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-N-(2-dimethylamino-ethyl)-benzamide

Participants

Reaction Steps

Using 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-yl)-benzoic acid (53.4 mg) obtained in Step A in Example 1-D-19 and N,N-dimethyl ethylenediamine (18 μl) instead of 3-(aminomethyl)pyridine, in the same manner as Step B in Example 1-D-19, 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-N-(2-dimethylamino-ethyl)-benzamide was obtained as a crude product. Then the PMB groups were removed according to Deprotection method 3, to obtain the desired compound (D-41) as a colorless solid (21.7 mg, 55%).

Provenance & Evidence