1-Propanesulfonyl chloride → HCID 67386456, compound

Participants

Reaction Steps

In the same manner as Example 1-D-02, using bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (40 mg) and propane-1-sulfonyl chloride (0.70 ml) instead of mesyl chloride, a crude product of bis-(4-methoxy-benzyl)-[5-[2-morpholin-4-yl-7-(propane-1-sulfonyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyrimidin-2-yl]-amine was obtained. Using a crude product (12 mg) of this bis-(4-methoxy-benzyl)-[5-[2-morpholin-4-yl-7-(propane-1-sulfonyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyrimidin-2-yl]-amine, the PMB groups were removed according to the above Deprotection method 2, to obtain 5-[2-morpholin-4-yl-7-(propane-1-sulfonyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyrimidin-2-ylamine as a colorless powder (5.4 mg, 77%).

Provenance & Evidence