Methyl 3-bromobenzoate → HCID 67386308, compound

Participants

Reaction Steps

Using bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (15.0 mg, 0.0278 mmol) and 3-bromobenzoic acid methyl ester (7.1 mg, 0.033 mmol) instead of 4-bromobenzoic acid methyl ester, in the same manner as Example 1-D-08, a crude product of 3-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-benzoic acid methyl ester was obtained, and then the PMB groups were removed according to the above Deprotection method 2, to obtain the desired compound (D-52) as a yellow powder (10.4 mg, 86%).

Provenance & Evidence