N,N-Dimethylpiperidin-4-amine → HCID 67384948, compound

Participants

Reaction Steps

Using {5-[7-(6-chloro-pyridin-3-yl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyrimidin-2-yl}-bis-(4-methoxy-benzyl)-amine (200 mg, 0.31 mmol) obtained in Step A in Example 1-D-48 and 4-dimethylaminopiperidine (59 mg, 0.46 mmol) instead of N,N,N′-trimethyl ethylenediamine, in the same manner as Example 1-D-48, amination was carried out, to obtain a crude product of [5′-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-dimethyl-amine as a yellow solid (197 mg), and then the PMB groups were removed according to the above Deprotection method 2, to obtain the desired compound (D-73) as a yellow powder (32 mg, 24%).

Provenance & Evidence