Methyl 4-bromobenzoate → HCID 67385716, compound

Participants

Reaction Steps

Using bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (120 mg) and 4-bromo-N-Boc-N-(3-hydroxy-propyl)-benzenesulfonamide (105 mg) obtained in the same manner as Example 1-D-80 instead of 4-bromobenzoic acid methyl ester in Example 1-D-08, in the same manner as Example 1-D-08, a crude product of 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-N-(3-hydroxy-propyl)-benzenesulfonamide was obtained, and then the PMB groups were removed according to the above Deprotection method 1, to obtain the desired compound (D-98) as a yellow powder (19 mg, 17%).

Provenance & Evidence