4-Nitrobenzoic Acid → (Morpholin-4-yl)(4-nitrophenyl)methanone

HRID 912226Notes

Reaction equation

HRID 912226 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[N:13]1([C:8]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)=[O:10])[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 61084-Nitrobenzoic AcidHCID 8083Morpholine

Product 1

HCID 220838(Morpholin-4-yl)(4-nitrophenyl)methanone

Procedure

Using 4-nitro-benzoic acid (334 mg) instead of 3-nitro-benzoic acid, and morpholine (209 μl) instead of 1-ethyl-piperazine, in the same manner as Step A in Example 1-D-101, the desired compound was obtained (363.5 mg, 77%).

Sources & evidence

ORD record
ord-cdbce59e57874d9d94aea97b5a6e45ee
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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