1-(2-Hydroxyethyl)piperazine → HCID 59244558, compound

Participants

Reaction Steps

Using N-2-hydroxyethylpiperazine instead of N-ethylpiperazine in Step B in Example 1-D-120, in the same manner as Step B in Example 1-D-120, a crude product of [2-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-thiazol-4-yl]-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone was obtained, and then the PMB groups were removed according to Deprotection method 1, to obtain the desired compound (D-121) as an ivory powder (20 mg, 29%).

Provenance & Evidence