4-Nitrobenzoic Acid → HCID 619141, compound

HRID 912239Notes

Reaction equation

HRID 912239 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[N:13]1([CH2:19][CH2:20][OH:21])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[OH:21][CH2:20][CH2:19][N:13]1[CH2:18][CH2:17][N:16]([C:8]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)=[O:10])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 61084-Nitrobenzoic AcidHCID 76771-(2-Hydroxyethyl)piperazine

Product 1

HCID 619141HCID 619141, compound

Procedure

Using 4-nitro-benzoic acid (320 mg) instead of 3-nitro-benzoic acid, and 2-piperazin-1-yl-ethanol (282 μl) instead of 1-ethyl-piperazine, in the same manner as Step A in Example 1-D-101, the desired compound was obtained as a crude product.

Sources & evidence

ORD record
ord-73546fa285494cc6be7c5da04e7bdc03
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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