反应详情

Using 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-benzaldehyde (70 mg) and morpholine (14 μl) instead of 1-methylpiperazine, in the same manner as Step B in Example 1-D-26, a crude product of bis-(4-methoxy-benzyl)-{5-[2-morpholin-4-yl-7-(4-morpholin-4-ylmethyl-phenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyrimidin-2-yl}-amine was obtained, and then the PMB groups were removed according to the above Deprotection method 3, to obtain the desired compound (D-126) as a pale brown powder (26 mg, 50%).

1. customthe PMB groups were removed