tert-Butyl 4-(3-bromobenzene-1-sulfonyl)piperazine-1-carboxylate → HCID 59244286, compound

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From 4-(3-bromo-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (prepared from 3-bromobenzenesulfonyl chloride and piperazine-1-carboxylic acid tert-butyl ester, 83 mg) instead of 1-(3-bromo-benzenesulfonyl)-4-ethyl-piperazine in Example 1-D-96, a crude product of 4-[3-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester was obtained, and then the PMB groups and BOC group were removed according to the above Deprotection method 1, to obtain the desired compound (D-132) as a yellow powder (32 mg, 33%).

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