tert-Butyl piperazine-1-carboxylate → HCID 59244782, compound

Participants

Reaction Steps

Using 3-[4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-propionic acid (61 mg) and piperazine-1-carboxylic acid tert-butyl ester (20 mg) instead of 3-(aminomethyl)pyridine, in the same manner as Step B in Example 1-D-19, 3-[4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-1-(4-tert-butyl-piperazin-1-yl)-propan-1-one was obtained, and further PMB group and BOC group were removed according to the above Deprotection method 2, to obtain the desired compound (D-168) as a pale yellow powder (14 mg, 31%).

Provenance & Evidence