1-(2-Hydroxyethyl)piperazine → HCID 59244908, compound

Participants

Reaction Steps

Using 3-[4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-propionic acid (100 mg) obtained in Step A in Example 1-D-168 and 2-piperazin-1-yl-ethanol (23 mg) instead of 3-(aminomethyl)pyridine, in the same manner as Step B in Example 1-D-19, 3-[4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-1-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-propan-1-one was obtained, and then the PMB groups were removed according to the above Deprotection method 2, to obtain the desired compound (D-170) as a pale yellow powder (20 mg, 25%).

Provenance & Evidence