HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodo-4-nitrobenzene → N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodo-4-nitrobenzene | HCID 12495 | — |
| Reactant | 1-(3-Aminopropyl)-4-methylpiperazine | HCID 78328 | — |
| Product | N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene | HCID 21975010 | — |
Reaction Steps
Using 1-iodo-4-nitro-benzene (500 mg) instead of 1-bromo-3-nitro-benzene, and 3-(4-methyl-piperazin-1-yl)-propylamine (379 mg) instead of morpholine, in the same manner as Step A in Example 1-D-105, the desired compound was obtained (432 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022205B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-e4660a3f5af040859863afab87d5fd01 |
| Source note | uspto-grants-2011_09 |