4-Bromo-3-methylbenzonitrile → HCID 67385926, compound

Participants

Reaction Steps

Using bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (300 mg) and 3-methyl-4-bromobenzonitrile (120 mg) instead of 4-bromobenzoic acid methyl ester used in Example 1-D-8, in the same manner as Example 1-D-07, a crude product of 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-3-methyl-benzonitrile was obtained, and then the PMB groups were removed according to the above Deprotection method 3 using 54 mg of the crude product, to obtain the desired compound (D-234) as an ivory powder (32 mg, 94%).

Provenance & Evidence