反应详情

To a methanol solution (10 ml) of 4-(4-methyl-3-nitro-phenyl)-morpholine (22 mg) obtained in Step A, zinc (65 mg) and ammonium chloride (16 mg) were added, followed by stirring at room temperature for 3 hours. After filtration through Celite, the solvent was distilled off under reduced pressure, followed by purification by silica gel column chromatography (dichloromethane/methanol=30/1), to obtain the desired compound as a colorless solid (17 mg, 90%).

1. filtrationAfter filtration through Celite
2. distillationthe solvent was distilled off under reduced pressure
3. customfollowed by purification by silica gel column chromatography (dichloromethane/methanol=30/1)