HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → [3,5-Difluoro-4-(4-methoxy-benzylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 59244777 | HCID 59244777 | — |
| Product | [3,5-Difluoro-4-(4-methoxy-benzylamino)-phenyl]-(4-methyl-piperazin-1-yl)-methanone | HCID 59244847 | — |
Reaction Steps
Using 3,5-difluoro-4-(4-methoxy-benzylamino)-benzoic acid (95.4 mg) obtained in Step B in Example 1-D-24 and 1-methyl-piperazine (43.3 μl) instead of 1-ethyl-piperazine, in the same manner as Step C in Example 1-D-24, the desired compound was obtained as a crude product (82 mg, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022205B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-cdab4e8553384ab8b7bb6ed9dc182ca4 |
| Source note | uspto-grants-2011_09 |