HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → [3,5-Difluoro-4-(4-methoxy-benzylamino)-phenyl]-morpholin-4-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 3,5-Difluoro-4-(4-methoxy-benzylamino)-benzoic acid | HCID 59244777 | — |
| Product | [3,5-Difluoro-4-(4-methoxy-benzylamino)-phenyl]-morpholin-4-yl-methanone | HCID 59244740 | — |
Reaction Steps
Using 3,5-difluoro-4-(4-methoxy-benzylamino)-benzoic acid (95.4 mg) obtained in Step B in Example 1-D-24 and morpholine (33.8 μl) instead of 1-ethyl-piperazine, in the same manner as Step C in Example 1-D-24, the desired compound was obtained as a crude product (111 mg, 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022205B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-9ddcad69ceb94f2e8828ebcf9f0f0bd5 |
| Source note | uspto-grants-2011_09 |