4-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine → 4-Methyl-5-(2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-ylamine

Participants

Reaction Steps

Using 4-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine (64 mg) obtained in Step C in Example 1-B-01 and bis-(4-methoxy-benzyl)-[4-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-amine (105 mg) obtained in Step A in Example 1-D-260 instead of bis-(4-methoxy-benzyl)-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]amine used in Step D in Example 1-B-01, the same operation as Step D in Example 1-B-01 was carried out, to obtain the desired compound (D-261) as a colorless powder (19 mg, 25%).

Provenance & Evidence