4-Pyridinemethanamine → HCID 67385441, compound

Participants

Reaction Steps

Using 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-benzoic acid (80.0 mg, 0.121 mmol) obtained in Step A in Example 1-D-19 and 4-(aminomethyl)pyridine (18.5 μl, 0.182 mmol) instead of 3-(aminomethyl)pyridine, amidation was carried out in the same manner as Step B in Example 1-D-19, to obtain a crude product of 4-[4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-N-pyridin-4-ylmethyl-benzamide as a brown solid (119 mg), and then the PMB groups were removed according to the above Deprotection method 3, to obtain the desired compound (D-264) as a yellow powder (46.7 mg, 76%).

Provenance & Evidence