Urea → HCID 67385222, compound

Participants

Reaction Steps

Using bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (80.0 mg, 0.148 mmol) and a crude product (59.7 mg) of 3-isocyanato-2-methyl-pyridine obtained in Step A instead of 2-chlorophenyl isocyanate, urea was formed in the same manner as Example 1-D-217, to obtain a crude product of 4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid (2-methyl-pyridin-3-yl)-amide as a yellow solid (103 mg), and then the PMB groups were removed according to the above Deprotection method 3, to obtain the desired compound (D-274) as a yellow powder (14.4 mg, 22%).

Provenance & Evidence