1-(2-Pyridyl)piperazine → HCID 67385318, compound

Participants

Reaction Steps

Using 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-benzoic acid (60.0 mg, 0.0909 mmol) obtained in Step A in Example 1-D-19 and 1-(2-pyridyl)piperazine (27.7 μl, 0.182 mmol) instead of 3-(aminomethyl)pyridine, amidation was carried out in the same manner as Step B in Example 1-D-19, to obtain a crude product of {4-[4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-(4-pyridin-2-yl-piperazin-1-yl)-methanone as a brown solid (88.2 mg), and then the PMB groups were removed according to the above Deprotection method 3, to obtain the desired compound (D-278) as a yellow powder (47.4 mg, 100%).

Provenance & Evidence