2-Piperazinylpyrimidine dihydrochloride → HCID 67385302, compound

Participants

Reaction Steps

Using 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-benzoic acid (60.0 mg, 0.0909 mmol) obtained in Step A in Example 1-D-19 and 1-(2-pyrimidyl)piperazine dihydrochloride (43.1 mg, 0.182 mmol) instead of 3-(aminomethyl)pyridine, amidation was carried out in the same manner as Step B in Example 1-D-19, to obtain a crude product of {4-[4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-(4-pyrimidin-2-yl-piperazin-1-yl)-methanone as a brown solid (131 mg), and then the PMB groups were removed according to the above Deprotection method 3, to obtain the desired compound (D-284) as a yellow powder (40.7 mg, 79%).

Provenance & Evidence