Methyl 4-bromobenzoate → HCID 67386008, compound

Participants

Reaction Steps

From bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (100 mg) and 1-[2-(4-bromo-phenyl)-ethanesulfonyl]-4-methyl-piperazine (94 mg) obtained in Step A in Example 1-D-296 instead of 4-bromobenzoic acid methyl ester used in Example 1-D-8, in the same manner as Example 1-D-08, a crude product of bis-(4-methoxy-benzyl)-[5-(7-{4-[2-(4-methyl-piperazine-1-sulfonyl)-ethyl]-phenyl}-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine was obtained, and then the PMB groups were removed according to the above Deprotection method 3, to obtain the desired compound (D-296) as a colorless solid (11 mg, 5%).

Provenance & Evidence