4-Morpholinopiperidine → HCID 67385319, compound

Participants

Reaction Steps

Using 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-benzoic acid (80.0 mg, 0.121 mmol) obtained in Step A in Example 1-D-19 and 4-morpholinopiperidine (41.3 mg, 0.242 mmol) instead of 3-(aminomethyl)pyridine, amidation was carried out in the same manner as Step B in Example 1-D-19, to obtain a crude product of {4-[4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-(4-morpholin-4-yl-piperidin-1-yl)-methanone as a yellow solid (82.0 mg), and then the PMB groups were removed according to the above Deprotection method 3, to obtain the desired compound (D-307) as a yellow powder (32.0 mg, 55%).

Provenance & Evidence