3-(Methylaminomethyl)pyridine → HCID 67385507, compound

Participants

Reaction Steps

Using 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-3-fluoro-benzoic acid (80.0 mg, 0.118 mmol) obtained in Step A in Example 1-D-21 and N-methyl-N-(3-pyridylmethyl)amine (21.6 mg, 0.177 mmol) instead of 1-pyridine-3-yl-piperazine, the amidation was carried out in the same manner as Step B in Example 1-D-21, to obtain a crude product of 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-3-fluoro-N-methyl-N-pyridin-3-ylmethyl-benzamide as a yellow solid (92.8 mg), and then the PMB groups were removed according to the above Deprotection method 3, to obtain the desired compound (D-318) as a yellow powder (38.0 mg, 59%).

Provenance & Evidence