反应详情

温度

60 °C

Compound A-09 (4-(3-hydroxyphenyl)-2-(morpholin-4-yl)-7-(pyridin-4-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine (34 mg, 0.09 mmol) obtained in Example 1-A-09 was dissolved in dimethylformamide (1 mL), and diisopropylethylamine (32 μL) and ethyl isocyanate (32 μL) were added, followed by stirring at 60° C. for 12 hours. The reaction mixture was poured onto water, followed by extraction with dichloromethane, and the organic layer was dried over sodium sulfate. After the drying agent was filtered off, followed by concentration under reduced pressure, and the resulting residue was purified by silica gel column chromatography (dichloromethane/methanol), to obtain the desired compound (colorless powder, 22 mg, 55%).

1. additionThe reaction mixture was poured onto water
2. extractionfollowed by extraction with dichloromethane
3. dry with materialthe organic layer was dried over sodium sulfate
4. filtrationAfter the drying agent was filtered off
5. concentrationfollowed by concentration under reduced pressure
6. customthe resulting residue was purified by silica gel column chromatography (dichloromethane/methanol)