Methyl iodide → HCID 67027448, compound

HRID 912403Notes

Reaction equation

HRID 912403 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:4][CH2:3]1.[I:14][CH3:15]>C(O)C>[I-:14].[CH3:1][N+:2]1([CH3:15])[CH2:7][CH2:6][N:5]([CH:8]2[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 17906154HCID 17906154, compound

Product 1

HCID 67027448HCID 67027448, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 50 mL flask was charged with 1.02 g of 1-methyl-4-cyclohexylpiperazine, 20 mL of anhydrous ethanol, and 0.88 g of iodomethane. After 3 days of stirring under a nitrogen atmosphere the solution was placed into a new flask and quenched with 200 mL ether producing a white crystalline solid. The solid was filtered and rinsed with additional ether and then dried in a vacuum oven overnight at 30° C. and −25 bar to give 1.74 g of 1,1-dimethyl-4-cyclohexylpiperazin-1-ium iodide.

Workup

  1. customwas placed into a new flask
  2. customquenched with 200 mL ether producing a white crystalline solid
  3. filtrationThe solid was filtered
  4. washrinsed with additional ether
  5. customdried in a vacuum oven overnight at 30° C.

Sources & evidence

ORD record
ord-e2231059d63546ebaccdb976c07faac3
Source dataset
uspto-grants-2011_09
Patent number
US08025863B2

Reaction notes

Loading…