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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 912441Generated: October 30, 2026

(2-Bromoethoxy)-tert-butyldimethylsilane → (S)-tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-oxoazepan-3-ylcarbamate

https://huagongshe.com/reaction/912441

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Bromoethoxy)-tert-butyldimethylsilaneHCID 3608067—
Reactant(S)-tert-Butyl (2-oxoazepan-3-yl)carbamateHCID 7022178—
Product(S)-tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-oxoazepan-3-ylcarbamateHCID 57736566—

Reaction Steps

(S)-tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-oxoazepan-3-ylcarbamate was prepared from compound (S)-tert-butyl 2-oxoazepan-3-ylcarbamate (Example 8) and (2-bromoethoxy)(tert-butyl)dimethylsilane according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 25% ethyl acetate/hexanes, to provide compound (2f) in 48% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026233B2
Source datasetuspto-grants-2011_09
ORD IDord-a45131e9c93346219d985667470407ce
Source noteuspto-grants-2011_09