Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)propyl methanesulfonate | HCID 57657542 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methanesulfonic Acid | HCID 6395 | — |
| Product | 6-[4-(3-aminopropoxy)-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile | HCID 59410669 | — |
Reaction Steps
A mixture of 3-[4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy]propyl methanesulfonate (500 mg), and ammonia in methanol (7M, 10 ml) was heated at 120° C. under microwave conditions for 20 minutes. After removal of solvent under vacuum, the expected product 6-[4-(3-aminopropoxy)-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile was obtained as methanesulphonic acid salt. 1H NMR (CD3OD) δ: 8.44 (s, 1H), 8.35-8.42 (m, 3H), 7.36 (d, 1H), 4.32 (t, 2H), 4.02 (s, 3H), 3.23 (t, 2H), 2.25 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08026236B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-da61375845654e7ab6fadc4a93cd79eb |
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| Source note | uspto-grants-2011_09 |
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