Acetyl chloride → HCID 53322116, compound

Participants

Reaction Steps

Acetyl chloride (0.012 ml) was added dropwise to a solution of 1-methyl-(6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile (25 mg) and diisopropylethylamine (0.051 ml) in THF (2 ml). The reaction mixture was stirred at room temperature for 18 hours. The product was then purified by acidic prep HPLC to give 6-(4-(2-(1-acetylpiperidine-4-yl)-ethoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile (7.2 mg).

Provenance & Evidence