反应详情

温度

100 °C

(2,6-Dichloro-3,5-dimethoxy-phenyl)-[3-(6-methanesulfinyl-pyrimidin-4-yl)-pyrazin-2-yl]-amine 7 (200 mg, 0.414 mmol) is suspended in ammonia/2-propanol solution (2M, 3 mL, 6 mmol) in a sealed tube. After stirring at 100° C. overnight, the reaction is cooled to room temperature. The light yellow solid is collected by filtration, washed with water and 2-propanol, and dried to afford the desired product (6-[3-(2,6-dichloro-3,5-dimethoxy-phenylamino)-pyrazin-2-yl]-pyrimidin-4-ylamine (40). The filtrate can be used for further purification to give an additional product.

1. temperaturethe reaction is cooled to room temperature
2. filtrationThe light yellow solid is collected by filtration
3. washwashed with water and 2-propanol
4. customdried