反应详情

To a solution of 4-methyl-5-(2-trifluoromethyl-phenyl)-2,3-dihydro-1H-pyrrole-3-carboxylic acid methyl ester (10 g, 35 mmol) in toluene was added 10% Pd/C (3.3 g). The resulting suspension was heated to reflux for 3 days. After cooling, the solids were removed by filtration. The filtrate was washed with toluene and concentrated under reduced pressure to yield an oil, which was purified by column chromatography (silica), eluting with EtOAc-hexane (1:1) to give the title compound (2.9 g, 29%). MS (ES): 284 (MH+).

1. temperatureThe resulting suspension was heated
2. temperatureto reflux for 3 days
3. temperatureAfter cooling
4. customthe solids were removed by filtration
5. washThe filtrate was washed with toluene
6. concentrationconcentrated under reduced pressure
7. customto yield an oil, which
8. customwas purified by column chromatography (silica)
9. washeluting with EtOAc-hexane (1:1)