Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | HCID 9794806 | HCID 9794806 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67387964 | HCID 67387964 | 61.7% |
Reaction Steps
Dissolved 10 mg huperzine A and 10 mg triethylamine in 5 mL dry THF; cooled the solution down to 0° C.; added ethyl chlorocarbonate (6 mg) and stirred the resultant reaction mixture for 4 hours; filtered to remove solid residues; after concentrating the filtrate, purified on prep TLC (chloroform:methanol=9:1) to yield 8 mg of pure title compound. MS: 315 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08026251B2 |
|---|
| Source dataset | uspto-grants-2011_09 |
|---|
| ORD ID | ord-1e8b0eb5811044b0aa6772d2aeac3e17 |
|---|
| Source note | uspto-grants-2011_09 |
|---|
