Ethyl cyanoacetate → HCID 4907107, compound

HRID 912651Notes

Reaction equation

HRID 912651 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9]([NH2:11])=[S:10])=[CH:3][CH:2]=1.[C:12]([CH2:14][C:15](OCC)=[O:16])#[N:13]>C(O)(=O)C>[NH2:13][C:12]1[N:8]([CH2:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[C:9](=[S:10])[NH:11][C:15](=[O:16])[CH:14]=1

Participants

4

Reactant 2

HCID 7764Ethyl cyanoacetateHCID 2826564HCID 2826564, compound

Product 1

HCID 4907107HCID 4907107, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared in accordance with the general method described in Example 11(b), using N-(pyridin-4-ylmethyl)thiourea (1.0 g, 5.98 mmol) and ethyl cyanoacetate (0.64 mL, 5.98), with the exception that a 4 h reaction time was used, and the solution was neutralized with acetic acid. The crude title compound was obtained (1.07 g, 76%) as a solid.

Workup

  1. customThe title compound was prepared in accordance with the general method
  2. customwith the exception that a 4 h reaction time

Sources & evidence

ORD record
ord-b8420d88671645a0b41c277d2f9bf5eb
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

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