Dichloromethane → HCID 86631114, compound

Participants

Reaction Steps

tert-Butyl 3-({[5-(aminocarbonyl)-1H-imidazol-4-yl]amino}methyl)-5-fluoro-1H-indole-1-carboxylate (0.15 g, 0.32 mmol, obtained from Example 6(b)) was dissolved in CH2Cl2. Benzoylisothiocyanate (0.06 g, 0.35 mmol) was added and the mixture was stirred at r.t. for 7 h. The mixture was concentrated in vacuo. Ammonia (7 N in methanol, 3 mL) was added and the mixture was heated at 80° C. for 1 h. The mixture was concentrated and the residue was dissolved in ethyl acetate and washed with water. The organic layer were dried (MgSO4) and concentrated in vacuo. The crude product-mixture was used in the next step without further purification. MS (ESI) m/z 414 (M−1).

Provenance & Evidence