Formamidine acetate → 3-(1H-benzimidazol-2-ylmethyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 5,6-diamino-1-(1H-benzimidazol-2-ylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (0.19 g, 0.65 mmol, obtained from Example 8(c)) in DMSO (2 mL) was added formamidine acetate (0.10 g, 0.98 mmol). The reaction mixture was heated to 70° C. for 2 h. Purification of the crude product using preparative HPLC gave the title compound (0.029 g, 15%) as a solid.

Provenance & Evidence