Ethyl cyanoacetate → HCID 178507963, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared in accordance with the general method described in Example 12(b) by using 1-(1H-pyrazol-3-ylmethyl)thiourea (1.39 g, 8.87 mmol obtained from Example 13(a)), sodium ethoxide (21% w/v, 8.62 mL, 26.6 mmol) and ethyl cyanoacetate (2.84 mL, 26.6 mmol) with the exception that it was necessary to maintain the cloudy solution at 5° C. overnight to obtain precipitation (0.87 g, 44% yield).

Provenance & Evidence