Formamidine acetate → HCID 178518764, compound

Participants

Reaction Steps

The title compound was prepared in accordance with the general method described in Example 12(d) by using 5,6-diamino-1-(1H-pyrazol-3-ylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (0.63 g, 2.64 mmol, obtained from Example 13(c)) and formamidine acetate (0.41 g, 3.95 mmol) with the exception that after the reaction mixture had cooled to r.t., water (10 mL) was added. The cloudy solution was maintained at 0° C. for 3 h and the precipitate that formed was collected by filtration, washed with water and methanol and dried in vacuo. The material was further purified by recrystallization from DMSO/water to give the title compound (0.20 g, 31% yield).

Provenance & Evidence