Formamidine acetate → HCID 24855506, compound

Participants

Reaction Steps

The title compound was prepared in accordance with the general method described in Example 12(d) by using 5,6-diamino-1-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (0.41 g, 1.6 mmol, obtained from Example 16(c)) and formamidine acetate (0.25 g, 2.4 mmol) with the exception that after the reaction mixture had cooled to r.t., water (20 mL) was added. The cloudy solution was maintained at 5° C. o.n. and the precipitate that formed was collected by filtration, washed with water and methanol and dried. The material was further purified by recrystallization from DMSO/water to give the title compound (59.9 g, 14% yield).

Provenance & Evidence