6-Butoxy-2-hydroxymethylpyridine → 6-Butoxypyridine-2-carbaldehyde

Participants

Reaction Steps

Activated manganese dioxide (2.40 g, 27.6 mmol) was added to a solution of (6-butoxy-pyridin-2-yl)methanol (0.52 g, 2.85 mmol, obtained from Example 17(c)) in anhydrous dichloromethane (5 mL). The resulting solution was heated to reflux for 2 h and then cooled to r.t. and 50 mL of dichloromethane added. The black solid was removed by filtration through silica gel and washed with dichloromethane. The combined filtrate was concentrated in vacuo providing the title compound (0.43 mg, 84%) as a light yellow oil.

Provenance & Evidence