Acetic Acid → HCID 86631139, compound

Participants

Reaction Steps

The title compound was prepared in accordance with the general method described in Example 17(e) using 4-butoxypyridine-2-carbaldehyde (0.67 g, 5.0 mmol, obtained from Example 18(d)), 5-aminoimidazole-4-carboxamide (0.81 g, 4.5 mmol), acetic acid (0.58 mL, 9.0 mmol) and sodium cyanoborohydride (0.57 g, 9.0 mmol) with the exception for the following change in work-up. The crude product was dissolved in ethyl acetate/water (1:1, 60 mL). The pH was adjusted to 8. The aqueous layer was separated and extracted with ethyl acetate (2×20 mL). The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo to give the title compound (1.20 g, 90% yield). MS (ESI) m/z 290 (M+1).

Provenance & Evidence