Acetic Acid → HCID 86761415, compound

Participants

Reaction Steps

The title compound was prepared in accordance with the general method described in Example 17(e) using 2-(pyridin-2-ylmethoxy)-propanal (0.875 g, 5.30 mmol, obtained from Example 20(b)), 5-aminoimidazole-4-carboxamide (0.668 g, 5.30 mmol), acetic acid (0.61 mL, 10.6 mmol) and sodium cyanoborohydride (0.666 g, 10.6 mmol) with the exception that the solution of aldehyde and carboxamide was stirred for 1 h and that sodium cyanoborohydride was added after 15 min. This yielded 1.32 g of the title compound, which was used in the next step without purification. MS (ESI) m/z 276 (M+1).

Provenance & Evidence