Acetic Acid → HCID 178513791, compound

Participants

Reaction Steps

The title compound was prepared in accordance with the general method described in Example 17(e) using quinoline-4-carbaldehyde (1.0 g, 6.4 mmol), 5-aminoimidazole-4-carboxamide (0.80 g, 6.4 mmol), acetic acid (0.44 mL, 7.6 mmol) and sodium cyanoborohydride (0.48 g, 7.6 mmol) with the exception that after stirring o.n., another portion of sodium cyanoborohydride (0.48 g, 7.6 mmol) was added and the mixture heated to reflux for 4 h. After cooling to r.t., the solution was concentrated in vacuo. A portion of the 2.9 g of crude material obtained was used in the next step without further purification. MS (ESI) m/z 268 (M+1).

Provenance & Evidence