Water → 2-[4-(2,6-Dichlorobenzyl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole

HRID 912762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 912762
[N:1]1([C:7]2[NH:11][C:10]3[CH:12]=[C:13]([C:16]([F:19])([F:18])[F:17])[CH:14]=[CH:15][C:9]=3[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:22]=1[CH2:23]Br.C([O-])(O)=O.[Na+].O>CN(C=O)C>[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:22]=1[CH2:23][N:4]1[CH2:5][CH2:6][N:1]([C:7]2[NH:11][C:10]3[CH:12]=[C:13]([C:16]([F:19])([F:17])[F:18])[CH:14]=[CH:15][C:9]=3[N:8]=2)[CH2:2][CH2:3]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 301591-Bromomethyl-2,6-dichlorobenzeneHCID 516892Sodium BicarbonateHCID 116662012-Piperazin-1-yl-6-trifluoromethyl-1H-benzoimidazole

Produkt 1

HCID 578351142-[4-(2,6-Dichlorobenzyl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of the benzoimidazole from step (a) above (96 mg, 0.36 mmol), 2,6-dichlorobenzyl bromide (86 mg, 0.36 mmol, Aldrich) and NaHCO3 (151 mg, 1.8 mmol) in DMF (2 mL) was stirred at room temperature for 16 h. Water (10 mL) was then added and the mixture was extracted with EtOAc (2×20 mL). The combined organic phases were washed with water (5 mL) and brine (5 mL) then dried over Na2SO4 and filtered. The solvent was removed in vacuo and the residue purified by silica gel chromatography, eluting with 40% EtOAc/hexane. The material was recrystallized from EtOAc/hexanes to give the title compound as a white solid. M.p. 254-256° C. MS (ESI, pos. ion) m/z: 429 (M+1).

Aufarbeitung

  1. extractionthe mixture was extracted with EtOAc (2×20 mL)
  2. washThe combined organic phases were washed with water (5 mL) and brine (5 mL)
  3. dry with materialthen dried over Na2SO4
  4. filtrationfiltered
  5. customThe solvent was removed in vacuo
  6. customthe residue purified by silica gel chromatography
  7. washeluting with 40% EtOAc/hexane
  8. customThe material was recrystallized from EtOAc/hexanes

Quellen und Nachweise

ORD-Eintrag
ord-e72e03879c954d8587eb3580ab1940f7
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026241B2

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