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HRID 912774作成日：2026年10月25日

1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine → 4-Bromo-6-trifluoromethyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole

https://huagongshe.com/reaction/912774

反応式

関与物質

役割名称HCID仕込み量
反応物1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazineHCID 667619—
反応物4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazoleHCID 11594585—
生成物4-Bromo-6-trifluoromethyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazoleHCID 57835199—

反応手順

The reaction of 1-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazine (212 mg, 0.8 mmol, ABCR) and 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole (210 mg, 0.7 mmol, Example 6b) under the conditions of Example 3c afforded the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 530 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08026241B2
出典データセットuspto-grants-2011_09
ORD IDord-1761a859c26c420483a5b53fb92b448c
出典メモuspto-grants-2011_09