HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Dichloropyridin-4-yl)piperazine → 2-[4-(3,5-Dichloropyridin-4-yl)piperazin-1-yl]-6-methyl-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Dichloropyridin-4-yl)piperazine | HCID 2799984 | — |
| Reactant | 2-chloro-6-methyl-1H-1,3-benzodiazole | HCID 11629655 | — |
| Product | 2-[4-(3,5-Dichloropyridin-4-yl)piperazin-1-yl]-6-methyl-1H-benzoimidazole | HCID 57835120 | — |
Reaction Steps
The benzoimidazole from step (b) above (0.287 g, 1.73 mmol) and 1-(3,5-dichloropyridin-4-yl)piperazine (0.4 g, 1.73 mmol, Maybridge) reacted under the conditions of Example 1d to give the title compound as a white solid. M.p. 251-254° C. MS (ESI, pos. ion) m/z: 362 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-89f4c95c294b4beebc72209b13dae09b |
| Source note | uspto-grants-2011_09 |