HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dichlorobenzimidazole → 6-Chloro-2-[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dichlorobenzimidazole | HCID 335473 | — |
| Reactant | 1-(3,5-Dichloropyridin-4-yl)piperazine | HCID 2799984 | — |
| Product | 6-Chloro-2-[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 57835081 | — |
Reaction Steps
The 2,5-dichloro-1H-benzoimidazole (0.37 g, 1.98 mmol, Example 20b) and 1-(3,5-dichloropyridin-4-yl)piperazine (0.46 g, 1.98 mmol, Maybridge) reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 258-260° C. MS (ESI, pos. ion) m/z: 382 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-b25e470e735e47739eba25f1e89b4650 |
| Source note | uspto-grants-2011_09 |