Diisopropylethylamine → 6-Bromo-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole

Participants

Reaction Steps

The 5-bromo-2-chloro-1H-benzoimidazole (0.115 g, 0.5 mmol, Example 23b), 1-(3-chloropyridin-2-yl)piperazine (0.198 g, 1 mmol, Example 3b) and N,N-diisopropylethylamine (0.35 mL, 2 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 207-208° C. MS (ESI, pos. ion) m/z: 394 (M+1).

Provenance & Evidence