Diisopropylethylamine → 2-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-5,6-dichloro-1H-benzoimidazole

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Reaction Steps

The 2,5,6-trichloro-1H-benzoimidazole (0.110 g, 0.5 mmol, Example 25b), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.234 g, 1 mmol, Example 3b) and N,N-diisopropylethylamine (0.35 mL, 2 mmol, Aldrich) were reacted under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 382 (M+1).

Provenance & Evidence